Eugene Spiro, born Eugen Spiro (April 18, 1874, Breslau, Silesia - September 26, 1972, New York City) was a German and American painter.
In 1904 Spiro was briefly married to the famous actress Tilla Durieux, who later married the important art dealer Paul Cassirer. His younger sister was the painter Baladine Klossowska.